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Placental extract ameliorates non-alcoholic steatohepatitis (NASH) by exerting protective effects on endothelial cells

Yamauchi A, Kamiyoshi A, Koyama T, Iinuma N, Yamaguchi S, Miyazaki H, Hirano E, Kaku T, Shindo T

Heliyon. 3: e00416: doi: 10.1016/j.heliyon.2017.e00416, 2017


Vasoprotective activities of the adrenomedullin-RAMP2 system in endothelial cells

Xian X, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Koyama T, Kawate H, Yang L, Liu T, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T

Endocrinology. 158(5):1359-1372, 2017


Endogenous calcitonin gene-related peptide regulates lipid metabolism and energy homeostasis in male mice

Liu T, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Yang L, Tanaka M, Xian X, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T

Endocrinology. 158(5).1194-1206. 2017


Adrenomedullin suppresses vascular endothelial growth factor-induced vascular hyperpermeability and Inflammation in retinopathy

Imai A, Toriyama Y, Iesato Y, Hirabayashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Zhai L, Dai K, Tanimura K, Liu T, Cui N, Yamauchi A, Murata T, Shindo T

Am J Pathol. 187(5):999-1015. 2017

Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques

Uemura T, Mori T, Kurihara T, Kawase S, Koike R, Satoga M, Cao X, Li X, Yanagawa T, Sakurai T, Shindo T, Tabuchi K

Sci Rep. 6:35861.doi:10.1038/srep35861,2016


The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis

Tanaka M, Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K, Taniguchi S, Shindo T

Cardiovasc Res. 111(4): 398-409, 2016


Adrenomedullin: A potential therapeutic target for retinochoroidal disease

Iesato Y, Yuda K, Chong K.T.Y, Tan X, Murata T, Shindo T, Yanagi Y

Prog Retin Eye Res. 52: 112-29, 2016


Effects of Adrenomedullin on Doxorubicin Induced Cardiac Damage in Mice

Yoshizawa T, Takizawa S, Shimada S, Tokudome T, Shindo T, Matsumoto K

Biol Pharm Bull. 39: 737-746, 2016


A non-inheritable maternal Cas9-based multiple-gene editing system in mice

Sakurai T, Kamiyoshi A,Kawate H, Mori C, Watanabe S, Tanaka M, Uetake R, Sato M, Shindo T

Sci Rep. 6:20011. doi:10.1038/srep20011, 2016


Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury

Ayuzawa N, Nagase M, Ueda K, Nishimoto M, Kawarazaki W, Marumo T, Aiba A, Sakurai T, Shindo T, Fujita T

Hypertension. 67(1): 99-106, 2016


Importance of Endogenous Atrial and Brain Natriuretic Peptides in Murine Embryonic Vascular and Organ Development

Tokudome T, Kishimoto I, Shindo T, Kawakami H, Koyama T, Otani K, Nishimura H, Miyazato M, Kohno M, Nakao K, Kangawa K

Endocrinology. 157(1): 358-67, 2016


Adrenomedullin-RAMP2 System in Vascular Endothelial Cells

Koyama T, Sakurai T,Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Shindo T

J Atheroscler Thromb. 22(7):647-653, 2015


Pathophysiological Function of Endogenous Calcitonin Gene-Related Peptide in Ocular Vascular Diseases

Toriyama Y, Iesato Y, Imai A, Sakurai T, Kamiyoshi A, Yuka Ichikawa-Shindo, Kawate H, Yamauchi A, Igarashi K, Tanaka M, Liu T, Xian X, Zhai L, Owa S, Murata T, Shindo T

Am J Pathol. 185(6):1783-1794, 2015


Functional differentiation of RAMP2 and RAMP3 in their regulation of the vascular system

Yamauchi A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Igarashi K, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T

J Mol Cell Cardiol. 77:73-85, 2014


Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia

Igarashi K, Sakurai T,Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Koyama T, Uetake R, Ihara M, Shindo T

Peptides. 62:21-31,2014


Calcitonin Gene-related Peptide Is Involved in Inflammatory Pain but Not in Postoperative Pain

Ishida K, Kawamata T, Tanaka S, Shindo T, Kawamata M

Anesthesiology. 121:1068-1079, 2014


A single blastocyst assay optimized for detecting CRISPR/CAS9 system-induced indel mutations in mice

Sakurai T, Watanabe S, Kamiyoshi A, Sato M, Shindo T

BMC Technol. 14:69, 2014


The combinational use of CRISPR/Cas9-based gene editing and targeted toxin tochnology enables efficient biallelic knockout of the ƒ¿-1,3-galactosyltransferase gene in porcine embryonic fibroblasts

Sato M, Miyoshi K, Nagao Y, Nishi Y, Ohtsuka M, Nakamura S, Sakurai T, Watanabe S

Xenotransplantation. 21(3):291-300, 2014


Adrenomedullin-RAMP2 System Suppresses ER Stress-Induced Tubule Cell Death and Is Involved in Kidney Protection

Uetake R,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Kawate H,Iesato Y,Yoshizawa T,Koyama T,Yang L,Toriyama Y,Yamauchi A,Igarashi K,Tanaka M,Kuwabara T,Mori K,Yanagita M,Mukoyama M,Shindo T

Plos One. 9(2):e87667,2014


Regulation of Adrenomedullin and its Family peptide by RAMP System-Lessons from Genetically Engineered Mice

Shindo T,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Shimoyama N,Iinuma N,Arai T,Miyagawa S

Curr Protein Pept Sci. 14:347-357,2013


Adrenomedullin-RAMP2 System Is Crucially Involved in Retinal Angiogenesis

Iesato Y,Toriyama Y,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Kawate H,Yoshizawa T,Koyama T,Uetake R,Yang L,Yamauchi A,Tanaka M,Igarashi K,Murata T,Shindo T

Am J Pathol .182(6):2380-2390,2013


Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury

Yang L,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Kawate H,Yoshizawa T,Koyama T,Iesato Y,Uetake R,Yamauchi A,Tanaka M,Toriyama Y,Igarashi K,Shindo T

J Mol Cell Cardiol. 59:55-56,2013

Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis

Koyama T,Ochoa-Callejero L,Sakurai T,Kamiyosi A,Ichikawa-Shindo Y,Iinuma N,Arai T,Yoshizawa T,Iesato Y,Lei Y,Uetake R,Okimura A,Yamauchi A,Tanaka M,Igarashi K,Toriyama Y,Kawate H,Adams RH,Kawakami H,Mochizuki N,Martinez A,Shindo T

Circulation 127(7):842-53,2013


Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity modifying protein2 system

Yoshizawa T,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Kawate H,Iesato Y,Koyama T,Uetake R,Yang L,Yamauchi A,Tanaka M,Yoriyama Y,Igarashi K,Nakada T,Kashihara T,Yamada M,Kawakami H,Nakanishi H,Taguchi R,Nakanishi T,Akazawa H,Shindo T

Hypertension 61(2):341-51,2013


Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein2 for adrenomedullin-specific binding

Kusano S,Kukimoto-Niino M,Hino N,Ohsawa N,Okuda K,Sakamoto K,Shirouzu M,Shindo T,Yokoyama S

Protein Sci 21(2):199-210,2012


Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis

Shindo T,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y

Curr Hypertensi Rev 7:217-227,2011


Induction of LYVE-1/stabilin-2-posotive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling

Arai T,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Iinuma N,Iesato Y,Koyama T,Yoshizawa T,Uetake R,Yamauchi A,Yang L,Kawate H,Ogawa S,Kobayashi A,Miyagawa S,Shindo T

Peptides 32(9):1855-65,2011


Improvement of a phiC31 integrase-based gene delivery system that confers high and continuous transgene expression

Watanabe S,Nakamura S,Sakurai T,Akasaka K,Sato M

N Biothechnical 28(4):312-319,2011


A novel glycosylation signal regulates transforming growth factor b receptors as evidenced by endo-b-galactosidase C expression in rodent cells

Watanabe S,Misawa M,Matsuzaki T,Sakurai T,Muramatsu T,Sato M

Glycobiology. 21(4):482-92,2011


Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver.

Iinuma N,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Arai T,Yoshizawa T,Koyama T,Uetake R,Kawate H,Muto S,Tagawa Y,Miyagawa S,Shindo T

Peptides 31:865-871,2010


Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.

Takeda N,Manabe I,Uchino Y,Eguchi K,Matsumuto S,Nishimura S,Shindo T,Sano M,Otsu K,Snider P,Conway SJ,Nagai R

J Clin Invest.120(1):254-65,2010



Endogenous a-calcitonin gene-related peptide mitigates liver fibrosis in chronic hepatitis induced by repeated administration of concanavalin A

Kamiyoshi A, Sakurai T, Shindo Y. Iinuma N, Kawate H, Yoshizawa T, Koyama T, Muto S, Shindo T.


Liver International 29(5):642-649,2009



Crystal
structure of the human receptor activity-modifying protein 1 extracellular domain.

Kusano S, Kukimoto-Niino M, Akasaka R, Toyama M, Terada T, Shirouzu M, Shindo T, Yokoyama S.


Protein Sci. 17(11):1907-14,2008




Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.

Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.


J Biol Chem. 283(36):24682-9. 2008




GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. 

Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T.  

J Clin Invest. 118(1):29-39,2008




Rapid zygosity determination in mice by SYBR Green real-time genomic PCR of a crude DNA solution. 

Sakurai T
, Kamiyoshi A, Watanabe S, Sato M, Shindo T.

Transgenic Res. 17(1):149-55,2008.




Adrenomedullin insufficiency increases allergen-induced airway hyperresponsiveness in mice. 

Yamamoto H, Nagase T, Shindo T, Teramoto S, Aoki-Nagase T, Yamaguchi Y, Hanaoka Y, Kurihara H, Ouchi Y. 

J Appl Physiol. 102(6):2361-8. 2007.



Disruption of mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in oocytes and somatic cells.

Nakanishi T, Kumagai S, Kimura M, Watanabe H, Sakurai T, Kimura M, Kashiwabara S, Baba T.


Biochem Biophys Res Commun. 364::14-19.,2007



Production of characterization of transgenic mice systemically expressing endo b-galactosidase C.

Watanabe S, Misawa M, Matsuzaki T, Sakurai T, Muramatsu T, Yokomine T, Sato M.

Glycobiology.  2008 Jan;18(1):9-19.




Endogenous aCGRP protects against concanavalin A-induced hepatitis in mice

Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Fukuchi J, Kawate H, Muto S, Tagawa Y, Shindo T

Biochem Biophys Res Commun.343(1):152-8. 2006



The synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6

Takeda N, Manabe I, Shindo T, Iwata H, Iimuro S, Kagechika H, Shudo K, Nagai R.


Arterioscler Thromb Vasc Biol. 26(5):1177-83. 2006



Folliculogenesis following syngeneic transplantation of young murine ovaries into the testes.

Sato M, Sakurai T, Kiryu K, Takeda M, Yasuoka Y.
:

Reprod. Med. Biol. 5, 71-77,
2006.



Preparation of enzymatically active human Myc-tagged-NCre recombinase exhibiting immunoreactivity with anti-Myc antibody.

Watanabe S, Homma D, Furusawa T, Sakurai T, Sato M. :

Mol. Reprod. Dev. 73,1345-1352 ,2006




Strain difference in tolerance to low-temperature treatment of fertilized mouse oocytes.

Sakurai
T, Watanabe S, Kimura M, Sato M. :

Reprod. Med. Biol. 5,43-50,
2006.



Testatin transgenic and knockout mice exhibit normal sex-differentiation.

Hasegawa K, Chuma S, Tada T, Sakurai T, Tamura M, Suemori H, Nakatsuji N.:

Biochem Biophys Res Commun. 341, 369-375,
2006.


Significance of the transcription factor KLF5 in cardiovascular remodeling.

Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I.


J Thromb Haemost. 3(8):1569-76. 2005.


Adrenomedullin Chapter 9: Knockout mice and transgenic mice

Shindo T

Kluwer academic press 167-174, 2005



Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation

Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G, Maemura K, Yamauchi T, Kubota N, Suzuki R,@Kitamura T, Akira S,
Kadowaki T, Nagai R.

Cell Metabolism 1: 27-39, 2005


Synthetic Retinoid Am80 Suppresses Smooth Muscle Phenotypic Modulation and In-Stent Neointima Formation by Inhibiting KLF5.

Fujiu K, Manabe I, Ishihara A, Oishi Y, Iwata H, Nishimura G, Shindo T, Maemura K, Kagechika H, Shudo K, Nagai R.

Circ Res. 97(11):1132-41,2005.


Angiogenic effects of adrenomedullin in ischemia and tumor growth.

Iimuro S, Shindo T, Moriyama N, Amaki T, Niu P, Takeda N, Iwata H, Zhang Y, Ebihara A, Nagai R:

Circ Res 95:(4):415-23, 2004

 

Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis and renal damage.

Niu P, Shindo T, Iwata H, Iimuro S, Takeda N, Zhang Y, Ebihara A, Suematsu Y, Kangawa K, Hirata Y, Nagai R:

Circulation 109::1789-1794,2004

 

Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa.

Fukushima Y, Matsui T, Saitoh T, Ichinose M, Tateishi K, Shindo T, Fujishiro M, Sakoda H, Shojima N, Kushiyama A, Fukuda S, Anai M, Ono H, Oka M, Shimizu Y, Kurihara H, Nagai R, Ishikawa T, Asano T, Omata M.

Eur J Pharmacol. 502(3):243-52, 2004

 

KLF5/BTEB2, a Kruppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy.

Nagai R, Shindo T, Manabe I, Suzuki T, Kurabayashi M.

Adv Exp Med Biol. 538::57-65, 2003

 

Accelerated cardiac hypertrophy and renal damage induced by angiotensin II in adrenomedullin knockout mice.

Niu P, Shindo T, Iwata H, Ebihara A, Suematsu Y, Zhang Y, Takeda N, Iimuro S, Hirata Y, Nagai R:

Hypertens Res :26: 731-36, 2003

 

Structural and functional characterization of gastric mucosa and central nervous system in histamine H(2) receptor-null mice.

Fukushima Y, Shindo T, Anai M, Saitoh T, Wang Y, Fujishiro M, Ohashi Y, Ogihara T, Inukai K, Ono H, Sakoda H, Kurihara Y, Honda M, Shojima N, Fukushima H, Haraikawa-Onishi Y, Katagiri H, Shimizu Y, Ichinose M, Ishikawa T,
Omata M, Nagai R, Kurihara H, Asano T:

Eur J Pharmacol 468(1)::47-58, 2003

 

Targeted disruption of adrenomedullin and alphaCGRP genes reveals their distinct biological roles.

Kurihara H, Shindo T, Oh-Hashi Y, Kurihar Y, Kuwaki T:

Hypertens Res 26 Suppl:S105-8, 2003

 

Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice.           

Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Suzuki E, Sata M, Satonaka H, Takeda R, Nagata D, Kakoki M, Hayakawa H, Kangawa K, Matsuo H, Kitamura T, Nagai R :

Hypertens Res 26 Suppl: S79-84, 2003

 

Gene expression in fibroblasts and fibrosis.Involvement in cardiac hypertrophy

Manabe I, Shindo T, Nagai R:

Circ Res 27::1103-1113, 2002

 

Protective effect of adrenomedullin against cardiac hypertrophy and renal damage.

Niu P, Shindo T, Ebihara A, Zhang Y, Kawanami D, Imai Y, Amaki T, Suematsu Y, Nagai R:

Journal of Cardiac Failure 8, Suppl5: S221, 2002

 

A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy

Yokoyama H, Wada T, Kobayashi K, Kuno K, Kurihara H, Shindo T, Matsushima K:
.

Nephrol Dial Transplant 17 Suppl 9::39-41, 2002    

 

Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice.

Aoki-Nagase T, Nagase T, Oh-Hashi Y, Shindo T, Kurihara Y, Yamaguchi Y, Yamamoto H, Tomita T, Ohga E, Nagai R, Kurihara H, Ouchi Y:

Am J Physiol Lung Cell Mol Physiol 283(5)::L963-70, 2002

 

Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.

Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Suzuki T, Morita H, Maemura K, Sata M, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R:

Nature Medicine 8(8):856-63, 2002

 

Resistance to neointimal hyperplasia and fatty streak formation in adrenomedullin overexpression mice.

Imai Y, Shindo T, Maemura K, Sata M, Saito Y, Kurihara Y, Akishita M, Osuga J, Ishibashi S, Tobe K, Morita H, Oh-hashi Y, Suzuki T, Maekawa H, Kangawa K, Minamino N, Yazaki Y, Nagai R, Kurihara H:

Arterioscler Thromb Vasc Biol 22(8):1310-5, 2002

 

Regulation of angiogenesis by the aging suppressor gene klotho.

Fukino K, Suzuki T, Saito Y, Shindo T, Amaki T, Kurabayashi M, Nagai R:

Biochem Biophys Res Commun 293:332-7, 2002

 

Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury.  Studies on transgenic/knockout mice of adrenomedullin gene

Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Kakoki M, Nagata D, Hayakawa H, Satonaka H, Sata M, Tojo A, Suzuki E, Kangawa K, Matsuo H, Kitamura T, Nagai R:
.

Circ Res 90:657-63, 2002

 

Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1.

Shindo T, Kurihara H, Maemura K, Kurihara Y, Ueda O, Suzuki H, Kuwaki T, Ju K-H, Wang Y, Ebihara A, Nishimatsu H, Moriyama N, Fukuda M, Akimoto Y, Hirano H, Morita H, Kumada M, Yazaki Y, Nagai R, Kimura K:

J. Mol. Med 80(2):105-16, 2002

 

Evidence for the physiological and pathological roles of adrenomedullin from genetic engineering in mice.

Imai Y, Shindo T, Maemura K, Kurihara Y, Ryozo N, Kurihara H:

Ann N Y Acad Sci 947:26-33, 2001

 

Elevated sympathetic nervous activity in mice deficient in ƒ¿CGRP.

Oh-hashi Y,* Shindo T* (*double 1st author), Kurihara Y, Imai T, Wang Y, Morita H, Imai Y, Kayaba Y, Nishimatsu H, Suematsu Y, Hirata Y, Yazaki Y, Nagai R, Kuwaki T, Kurihara H:

Circ Res 89:983-90, 2001

 

Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.

Shindo T, Kurihara Y, Nishimatsu H, Moriyama N, Kakoki M, Wang Y, Imai Y, Ebihara A, Kuwaki T, Ju K-H, Minamino N, Kangawa K, Ishikawa T, Fukuda M, Akimoto Y, Kawakami H, Imai T, Morita H, Yazaki Y, Nagai R, Hirata H, Kurihara H:

Circulation 104:1964-71, 2001

 

Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice.

Imai T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H, Suematsu M, Katayama S:

Circ Res 89(1):55-62, 2001

 

Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury.

Morita H, Kurihara H, Yoshida S, Saito Y, Shindo T, Oh-Hashi Y, Kurihara Y, Yazaki Y, Nagai R:

Circulation 103(1):133-9, 2001

@

Pathophysiological assessment of adrenomedullin by mice gene engineering approach.

Shindo T, Kurihara H, Maemura K, Kurihara Y, Minamino N, Kangawa K, Yazaki Y, Nagai R:

J Submicroscopic Cytology & Pathology 32 (3):436, 2000

 

ADAMTS-1: A metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function.

Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Imai T, WangY, Oh-hashi Y, Morita H, Ishikawa T, Yazaki Y, Matsushima K:

J Clin Invest 105(10):1345-52, 2000

 

Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature. 

Shindo T, Kurihara H, Maemura K, Kurihara Y, Kuwaki T, Izumida T, Minamino N, Ju K, Morita H, Oh-hashi Y, Kumada M, Kangawa K, Nagai R, Yazaki Y:

Circulation 101(19):2309-16, 2000

 

Evidence for association between paraoxonase gene polymorphisms and atherosclerotic diseases.

Imai Y, Morita H, Kurihara H, Sugiyama T, Kato N, Ebihara A, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Yazaki Y:

Atherosclerosis 149(2):435-42, 2000

 

Responses of blood pressure and catecholamine metabolism to high salt loading in endothelin-1 knockout mice.

Morita H, Kurihara H, Kurihara Y, Kuwaki T, Shindo T, Oh-hashi Y, Kumada M, Yazaki Y:

Hypertens Res 22(1):11-6, 1999

 

Polymorphism of the methionine synthase gene : association with homocysteine metabolism and late-onset vascular diseases in the Japanese population.

Morita H, Kurihara H, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Yazaki Y:

Arterioscler Thromb Vasc Biol 19(2):298-302, 1999

 

Upregulation of endothelin-1 and adrenomedullin gene expression in the mouse endotoxin shock model.

Shindo T, Kurihara H, Kurihara Y, Morita H, Yazaki Y:

J Cardiovasc Pharmacol 31:S541-4, 1998

 

Cardiac sarcoidosis.

Shindo T, Kurihara H, Ohishi N, Morita H, Maemua K, Kurihara Y, Tsuneyoshi H, Chi H, Yamaoki K, Yazaki Y:

Circulation 97(13):1306-7, 1998

 

Systemic and renal response to salt loading in endothelin-1 knockout mice.

Morita H, Kurihara H, Kurihara Y, Shindo T, Kuwaki T, Kumada M, Yazaki Y:

J Cardiovasc Pharmacol 31:S557-60, 1998

 

Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese

Morita H, Kurihara H, Tsubaki S, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Kitamura K, Yazaki Y:   .

Arterioscler Thromb Vasc Biol 18(9):1465-9, 1998

 

Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease.

Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yazaki Y:

Circulation 95(8):2032-6, 1997


Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines.

Shindo T, Ikeda U, Ohkawa F, Kawahara Y, Yokoyama M, Shimada K:

Cardiovasc Res 29(6):813-9, 1995

 

Aneurysmal dilatation of the pulmonary trunk with mild pulmonic stenosis.

Shindo T, Kuroda T, Watanabe S, Hojo Y, Sekiguchi H, Shimada K:

Intern Med 34(3):199-202, 1995


Nitric oxide synthesis in rat cardiac myocytes and fibroblasts.

Shindo T, Ikeda U, Ohkawa F, Takahashi M, Funayama H, Nishinaga M, Kawahara Y, Yokoyama M, Kasahara T, Shimada K:

Life Sci 55(14):1101-8, 1994

 

Suppression of cytotoxin-induced cell death in isolated hepatocytes by tea catechins

Kagaya N, Tagawa Y et al. 

Eur J Pharmacol 450(3):231-236,2002

 

Interaction of rubratoxin B with serum albumin. 

Kagaya N, Kamiyoshi A, Tagawa Y et al.

Micotoxins
55(1):23-26,2005 .

 

Tumor necrosis-alpha is required for gastritis induced by Helicobacter felis infection in mice.

Hasegawa S, Nishikawa S, Miura T, Saito Y, Madarame H, Sekikawa K, Tagawa Y et al. 

Microb. Pathog.  37:119-124, 2004

 

Comparative Study on Adhesive Performance of Functional Monomers.

Yoshida, Y., K. Nagakane, R. Fukuda, Y. Nakayama, M. Okazaki, H. Shintani, S. Inoue, Y. Tagawa et al.

J. Dental Research, 83:454-458, 2004   

 

Liver protection by bis(maltolato)zinc(II) complex.

Kawase, M., N. Kagaya, S. Akamatsu, A. Kamiyoshi, S. Muto, Y. Tagawa, and Y. Yagi.:

Exp. Anim.  53:1-9, 2004

 

Novel function of rare catechin, epigallocatechin-3-(3ff-O-methyl)gallate, against cold injury in primary rat hepatocytes.  

Kagaya, N., Y. Hara, R. Saijo, A. Kamiyoshi, Y. Tagawa et al. J. Biosci. Bioeng. 96:559-563, 2003

 

Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on FcgR and IFN-g.

Sehra, S., Pynaert, G.., Tournoy, K., Haegenman, A., Matthys, P., Tagawa, Y. et al.  

J. Immunol.
, 171:2080-2089,2003

 

Survival and function of mouse embryonic stem cell-derived cardiomyocytes in ectopic transplants.

Johkura, K., Cui, L., Suzuki, A., Teng, R., Kamiyoshi, A., Okamura, S., Kubota, S., Zhao, X., Asanuma, K., Okouchi, Y., Ogiwara, N., Tagawa, Y. et al.:

Cardiovascular Research 58:435-443, 2003

 

Differences between BALB/c and C57BL/6 in mouse hepatitis virus replication in primary hepatocyte culture.

Kyuwa, S., Kawamura, S., Tagawa, Y. et al.:

Exp. Anim.,
52:81-84, 2003

 

IL-1-induced tumor necrosis factor-? elicits inflammatory cell infiltration in the skin by inducing IFN-g-inducible protein 10 in the elicitation phase of the contact hypersensitivity response.

Nakae, S., Komiyama, Y., Narumi, S., Sudo, K., Horai, R., Tagawa, Y. et al.:

Int.
Immunol. , 15: 251-260, 2003

 

Suppression of cytotoxin-induced cell death in isolated hepatocytes by tea catechins.

Kagaya, N., Tagawa, Y. et al. : Eur. J. Pharmacol. 450: 231-236, 2002

 

Inhibition of B16 melanoma metastasis by interferon-gamma through direct inhibition of cell proliferation and activation of anti-tumor host mechanisms.

Kakuta, S., Tagawa, Y. et al.:

Immunology. 105: 92-100, 2002

 

Comparison of host resistance to primary and secondary Listeria monocytogenes infections in mice by intranasal and intravenous routes.

Mizuki, M., Nakane, A., Sekikawa, K., Tagawa, Y. et al.:

Infect. Immun. 70:4805-4811, 2002

 

Roles of gamma interferon and tumor necrosis factor-alpha in shiga toxin lethality.

Sasaki, S., Omoe, K., Tagawa, Y. et al.:

Microbial Pathogenesis.
33: 43-47, 2002.

 

Acute hepatic failure in IFN-g-deficient BALB/c mice after murine coronavirus infection.

Kyuwa, S., Shibata, S., Tagawa, Y. et al.:

Virus Res. 83: 169-177, 2002.

 

Enhancing effect of zinc on hepatoprotectivity of epigallocatechin gallate in isolated rat hepatocytes.

Kagaya, N., Kawase, M., Maeda, H., Tagawa, Y. et al.:

Biol.Pharm.Bull. 25: 1156-1160, 2002.

 

Effect of 6-hydroxydopamine on host resistance against Listeria monocytogenes infection.

Miura, T., Kudo, T., Matsuki, A., Sekikawa, K., Tagawa, Y. et al.:

Infect. Immun.  69:7234-7241, 2001

 

Organ infectivity of Toxoplasma gondii in interferon-gamma knockout mice.

Norose, K., Mun, H. S., Aosai, F., Chen, M., Hata, H., Tagawa, Y. et al.:

J. Parasitol.
87:447-452, 2001

 

A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage plasmodium berghei XAT Infection.

Yoneto, T., Waki, S., Takai, T., Tagawa, Y. et al.

: J. Immunol. 166: 6236-6241, 2001

 

The severity of hepatic lesion after intraperitoneal JHMV infection in IFN-gamma deficient mice is parallel to viral replication in hepatocytes in vitro.

Kyuwa S, Kawamura S, Shibata S, Machii K, Tagawa Y. et al.:

Adv Exp Med Biol. 494:95-99, 2001

 

Bimodal role of endogenous interleukin-6 in concanavalin A-induced hepatitis in mice.

Tagawa, Y. et al.:

J. Leukoc. Biol. 67:90-96, 2000

 

Lipopolysaccharide-induced HIV-1 expression in transgenic mice is mediated by tumor necrosis factor-ƒ¿ and interleukin-1, but not by interferon-g nor interleukin-6.

Tanaka, J., H. Ozaki, J. Yasuda, R. Horai, Y. Tagawa. et al.:

AIDS 14:1299-1307, 2000

 

Interleukin-4 and interleukin-10 are involved in host resistance to Staphylococcus aureus infection through regulation of gamma interferon.

Sasaki, S., S. Nishikawa, T. Miura, M. Mizuki, K. Yamada, H. Madarame, Y. Tagawa, Y. Iwakura, and A. Nakane. :

Infect. Immun. 68:2424-2430, 2000

 

Roles of endogenous cytokines in liver apoptosis of mice in lethal Listeria monocytogenes infection.

Miura, T., S. Nishikawa, S. Sasaki, K. Yamada, S. Hasegawa, D. Mizuki, M. Mizuki, I. Hatayama, K. Sekikawa, Y. Tagawa, Y. et al.: FEMS Immunol. Med. Microbiol. 28:335-341, 2000

 

Toxoplasma gondi Hsp 70 as a danger signal in tosoplasma gondi-infected mice. 

Mun H. S., F. Aosai, K. Norose, M. Chen, H. Hata, Y. Tagawa, Y. et al.:

Cell stress Chaperones. 5: 328-335, 2000

 

Interferon-g priming is not critical for IL-12 production of murine spleen cells.

Hino, A., O. Igarashi, Y. Tagawa, Y. et al.:

Cytokine.
12:12-20, 2000

 

Hematological characteristics of rats spontaneously developing eosinophilia.

Matsumoto, K., N. Matsushita, H. Tomozawa, and Y. Tagawa.

Exp. Anim. 49:211-215, 2000

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