論文

Receptor activity-modifying proteins of adrenomedullin (RAMP2/3): Roles in the pathogenesis of ARDS
Kasahara T, Tanaka M, Zhao Y, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Matsuda Y, Zhang Y, Guo Q, Li P, Hoshiyama K, Li J, Onishi N, Hayashi M, Sanjo H, Ishida K, Tanaka S, Kawamata M, Shindo T
Peptides. 171: 171118. 2024

Role of Adrenomedullin2/Intermedin in the Pathogenesis of Neovascular Age-related Macular Degeneration
Kakihara S, Matsuda Y, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Tanaka M, Ichikawa-Shindo Y, Kawate H, Zhao Y, Zhang Y, Guo Q, Li P, Onishi N, Murata T, Shindo T
Lab Invest. 103(4): 100038. 2023

Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation
Tokuyama T, Uosaki H, Sugiura A, Nishitai G, Takeda K, Nagashima S, Shiiba I, Ito N, Amo T, Mohri S, Nishimura A, Nishida M, Konno A, Hirai H, Ishido S, Yoshizawa T, Shindo T, Takeda S, Kinugawa S, Inatome R, Yanagi S
iScience 25(7): 104582. 2022

Studies on safety and efficacy of particles containing a mixture of hydroxyapatite-argentum-titanium oxide(HAT) and sheets coated with HAT particles to be used in masks to improve nasal allegy: Ⅱ. Cellular, in vivo, and clinical studies
Okazaki N, Yamaki D, Takei T, Shimizu M, Kamatani N, Shindo T
Eur Arch Otorhinolaryngol. 279(9): 4425-33. 2022

Calcitonin gene-related peptide is not involved in neuropathic pain induced by partial sciatic nerve ligation in mice
Ishida K, Tanaka S, Shen D, Matsui S, Fuseya S, Shindo T, Kawamata M
Neurosci Lett. 778:136615. 2022

Receptor Activity Modifying Protein RAMP Sub-Isoforms andTheir Functional Differentiation, Which Regulates Functional Diversity of Adrenomedullin
Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Sakurai T
Biology. 11(5): 788. 2022

An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility
Negishi K, Aizawa K, Shindo T, Suzuki T, Sakurai T, Saito Y, Miyakawa T, Tanokura M, Kataoka Y, Maeda M, Tomida S, Morita H, Takeda N, Komuro I, Kario K, Nagai R, Imai Y
Sci Rep. 12(1):8844. 2022

Adrenomedullin ameliotates pulmonary fibrosis by regulating TGF-β-Smads signaling and myofibroblast differentiation
Wei Y, Tanaka M,Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T
Endocrinology. 162(8), 1-22. 2021

Production of single- and multiple- gene-modified mice via maternal SpCas9-based gene editing
Sakurai T, Shindo T
STAR Protoc. 2(2): 100509. 2021

Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a coss-sectional study
Koyama T, Kuriyama N, Suzuki Y, Saito S, Tanaka R, Iwao M, Tanaka M, Maki T, Itoh H, Ihara M, Shindo T,Uehara R
Sci Rep. 11(1): 305. . 2021

Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress
Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T
Endocrinology. 162(3): 1-20. 2021

Adrenomedullin-Receptor Activity-Modifying Protein 2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration
Tanaka M, Kakihara S, Hirabayashi K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Yamauchi A, Murata T, Shindo T
Am J Pathol. 191(4): 652-668. 2021

Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis
Yamauchi A, Tone T, Toledo A, Igarashi K, Sugimoto K, Miyai H, Deng D, Nakamura J, Lim HS, Kaku T, Hirano E, Shindo T
Biomed Res. 41(1): 1-12. 2020

Investigation of the therapeutic mechanism of subthreshold micropulse laser irradiation in retina
Hirabayashi K, Kakihara S, Tanaka M, Shindo T, Murata T
Graefes Arch Clin Exp Ophthalmol. 258(5): 1039-1047. 2020

Production of genetically engineered mice with higher efficiency, lower mosaicisim, and multiplexing capability using maternally expressed Cas9
Sakurai T, Kamiyoshi A, Kawate H, Watanabe S, Sato M, Shindo T
Sci Rep. 10(1): 1091. 2020

Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts
Dai K, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Matsui S, Shindo T
Oncogene.　39(9): 1914-1930.2020

Endogenous calcitonin gene-related peptide deficiency exacerbates postoperative lymphedema by suppressing lymphatic capillary formation and M2 macrophage accumulation
Matsui S, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Dai K, Cui N, Wei Y, Tanaka M, Kakihara S, Nakamura K, Yamauchi A, Ishida K, Tanaka S, Kawamata M, Shindo T
Am J Pathol. 189(12): 2487-2502. 2019

Placental extract suppresses cardiac hypertrophy and fibrosis in an angiotensin Ⅱ-induced cachexia model in mice
Yamauchi A, Kamiyoshi A, Sakurai T, Miyazaki H, Hirano E, Lim HS, Kaku T, Shindo T
Heliyon. 5(10):e02655. doi:10.1016/j.heliyon.2019.e02655. 2019

Porcine placental extract facilitates memory and learning in aged mice
Yamauchi A, Tone T, Sugimoto K, Lim HS, Kaku T, Tohda C, Shindo T, Tamada K, Mizukami Y, Hirano E
Food Sci Nutr. 7(9): 2995-3005. 2019

Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase
Sakurai T, Kamiyoshi A, Takei N, Watanabe S, Sato M, Shindo T
Sci Rep. 9:9923.doi.org/10.1038/s41598-019-46357-8. 2019

Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism
Yamauchi A, Kamiyoshi A, Sakurai T, Miyazaki H, Hirano E, Lim HS, Kaku T, Shindo T
Heliyon. 5(5):e01637. doi:10.1016/j.heliyon.2019.e01637.2019

Development of a novel model of central retinal vascular occlusion and therapeutic potential of adrenomedullin-receptor activity modifying protein 2 system
Hirabayashi K, Tanaka M, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Dai K, Cui N, Wei Y, Nakamura K, Iida S, Matsui S, Yamauchi A, Murata T, Shindo T
Am J Pathol. 189(2): 449-466.2019

Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system
ShindoT, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Sakurai T
Peptides. 111:55-61.2019

RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders
Liu T, Kamiyoshi A, Tanaka M, Iida S, Salirao T, Ichikawa-Shindo Y, Kawate H, Hirabayashi K, Dai K, Cui N, Tanaka M, Wei Y, Nakamura K, Matsui S, Yamauchi A, Shindo T
Peptides. 110:10-18. 2018

Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline
Zahi L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Xian X, Hirabayashi K, Dai K, Cui N, Tanimura K, Liu T, Wei Y, Tanaka M, Tomiyama H, Yamauchi A, Igarashi K, Shindo T
J Hypertens. 36(4):876-891. 2018

Placental extract ameliorates non-alcoholic steatohepatitis (NASH) by exerting protective effects on endothelial cells
Yamauchi A, Kamiyoshi A, Koyama T, Iinuma N, Yamaguchi S, Miyazaki H, Hirano E, Kaku T, Shindo T
Heliyon. 3(9): e00416: doi: 10.1016/j.heliyon.2017.e00416. 2017

Vasoprotective activities of the adrenomedullin-RAMP2 system in endothelial cells
Xian X, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Koyama T, Kawate H, Yang L, Liu T, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T
Endocrinology. 158(5):1359-1372. 2017

Endogenous calcitonin gene-related peptide regulates lipid metabolism and energy homeostasis in male mice
Liu T, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Yang L, Tanaka M, Xian X, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T
Endocrinology. 158(5).1194-1206. 2017

Adrenomedullin suppresses vascular endothelial growth factor-induced vascular hyperpermeability and Inflammation in retinopathy
Imai A, Toriyama Y, Iesato Y, Hirabayashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Zhai L, Dai K, Tanimura K, Liu T, Cui N, Yamauchi A, Murata T, Shindo T
Am J Pathol. 187(5):999-1015. 2017

Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques
Uemura T, Mori T, Kurihara T, Kawase S, Koike R, Satoga M, Cao X, Li X, Yanagawa T, Sakurai T, Shindo T, Tabuchi K
Sci Rep. 6:35861.doi:10.1038/srep35861. 2016

The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis
Tanaka M, Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K, Taniguchi S, Shindo T
Cardiovasc Res. 111(4): 398-409, 2016

Adrenomedullin: A potential therapeutic target for retinochoroidal disease
Iesato Y, Yuda K, Chong K.T.Y, Tan X, Murata T, Shindo T, Yanagi Y
Prog Retin Eye Res. 52: 112-29. 2016

Effects of adrenomedullin on doxorubicin induced cardiac damage in mice
Yoshizawa T, Takizawa S, Shimada S, Tokudome T, Shindo T, Matsumoto K
Biol Pharm Bull. 39: 737-746. 2016

A non-inheritable maternal Cas9-based multiple-gene editing system in mice
Sakurai T, Kamiyoshi A,Kawate H, Mori C, Watanabe S, Tanaka M, Uetake R, Sato M, Shindo T
Sci Rep. 6:20011. doi:10.1038/srep20011. 2016

Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury
Ayuzawa N, Nagase M, Ueda K, Nishimoto M, Kawarazaki W, Marumo T, Aiba A, Sakurai T, Shindo T, Fujita T
Hypertension. 67(1): 99-106. 2016

Importance of Endogenous Atrial and Brain Natriuretic Peptides in Murine Embryonic Vascular and Organ Development
Tokudome T, Kishimoto I, Shindo T, Kawakami H, Koyama T, Otani K, Nishimura H, Miyazato M, Kohno M, Nakao K, Kangawa K
Endocrinology. 157(1): 358-67. 2016

Adrenomedullin-RAMP2 System in Vascular Endothelial Cells
Koyama T, Sakurai T,Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Shindo T
J Atheroscler Thromb. 22(7):647-653. 2015

Pathophysiological Function of Endogenous Calcitonin Gene-Related Peptide in Ocular Vascular Diseases
Toriyama Y, Iesato Y, Imai A, Sakurai T, Kamiyoshi A, Yuka Ichikawa-Shindo, Kawate H, Yamauchi A, Igarashi K, Tanaka M, Liu T, Xian X, Zhai L, Owa S, Murata T, Shindo T
Am J Pathol. 185(6):1783-1794. 2015

Functional differentiation of RAMP2 and RAMP3 in their regulation of the vascular system
Yamauchi A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Igarashi K, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T
J Mol Cell Cardiol. 77:73-85. 2014

Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia
Igarashi K, Sakurai T,Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Koyama T, Uetake R, Ihara M, Shindo T
Peptides. 62:21-31. 2014

Calcitonin gene-related peptide is involved in inflammatory pain but not in postoperative pain
Ishida K, Kawamata T, Tanaka S, Shindo T, Kawamata M
Anesthesiology. 121:1068-1079. 2014

A single blastocyst assay optimized for detecting CRISPR/CAS9 system-induced indel mutations in mice
Sakurai T, Watanabe S, Kamiyoshi A, Sato M, Shindo T
BMC Technol. 14:69. 2014

The combinational use of CRISPR/Cas9-based gene editing and targeted toxin tochnology enables efficient biallelic knockout of the α-1,3-galactosyltransferase gene in porcine embryonic fibroblasts
Sato M, Miyoshi K, Nagao Y, Nishi Y, Ohtsuka M, Nakamura S, Sakurai T, Watanabe S
Xenotransplantation. 21(3):291-300. 2014

Adrenomedullin-RAMP2 System Suppresses ER Stress-Induced Tubule Cell Death and Is Involved in Kidney Protection
Uetake R,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Kawate H,Iesato Y,Yoshizawa T,Koyama T,Yang L,Toriyama Y,Yamauchi A,Igarashi K,Tanaka M,Kuwabara T,Mori K,Yanagita M,Mukoyama M,Shindo T
Plos One. 9(2):e87667. 2014

Regulation of Adrenomedullin and its Family peptide by RAMP System-Lessons from Genetically Engineered Mice
Shindo T,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Shimoyama N,Iinuma N,Arai T,Miyagawa S
Curr Protein Pept Sci. 14:347-357. 2013

Adrenomedullin-RAMP2 System Is Crucially Involved in Retinal Angiogenesis
Iesato Y,Toriyama Y,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Kawate H,Yoshizawa T,Koyama T,Uetake R,Yang L,Yamauchi A,Tanaka M,Igarashi K,Murata T,Shindo T
Am J Pathol .182(6):2380-2390. 2013

Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury
Yang L,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Kawate H,Yoshizawa T,Koyama T,Iesato Y,Uetake R,Yamauchi A,Tanaka M,Toriyama Y,Igarashi K,Shindo T
J Mol Cell Cardiol. 59:55-56. 2013

Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis
Koyama T,Ochoa-Callejero L,Sakurai T,Kamiyosi A,Ichikawa-Shindo Y,Iinuma N,Arai T,Yoshizawa T,Iesato Y,Lei Y,Uetake R,Okimura A,Yamauchi A,Tanaka M,Igarashi K,Toriyama Y,Kawate H,Adams RH,Kawakami H,Mochizuki N,Martinez A,Shindo T
Circulation 127(7):842-53. 2013

Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity modifying protein2 system
Yoshizawa T,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Kawate H,Iesato Y,Koyama T,Uetake R,Yang L,Yamauchi A,Tanaka M,Yoriyama Y,Igarashi K,Nakada T,Kashihara T,Yamada M,Kawakami H,Nakanishi H,Taguchi R,Nakanishi T,Akazawa H,Shindo T
Hypertension 61(2):341-51. 2013

Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein2 for adrenomedullin-specific binding
Kusano S, Kukimoto-Niino M, Hino N,Ohsawa N, Okuda K, Sakamoto K, Shirouzu M, Shindo T, Yokoyama S
Protein Sci 21(2):199-210. 2012

Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis
Shindo T,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y
Curr Hypertensi Rev 7:217-227. 2011

Induction of LYVE-1/stabilin-2-posotive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling
Arai T,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Iinuma N,Iesato Y,Koyama T,Yoshizawa T,Uetake R,Yamauchi A,Yang L,Kawate H,Ogawa S,Kobayashi A,Miyagawa S,Shindo T
Peptides 32(9):1855-65. 2011

Improvement of a phiC31 integrase-based gene delivery system that confers high and continuous transgene expression
Watanabe S,Nakamura S,Sakurai T,Akasaka K,Sato M
N Biothechnical 28(4):312-319. 2011

A novel glycosylation signal regulates transforming growth factor b receptors as evidenced by endo-b-galactosidase C expression in rodent cells
Watanabe S,Misawa M,Matsuzaki T,Sakurai T,Muramatsu T,Sato M
Glycobiology. 21(4):482-92. 2011

Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver.
Iinuma N,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Arai T,Yoshizawa T,Koyama T,Uetake R,Kawate H,Muto S,Tagawa Y,Miyagawa S,Shindo T
Peptides 31:865-871. 2010

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.
Takeda N,Manabe I,Uchino Y,Eguchi K,Matsumuto S,Nishimura S,Shindo T,Sano M,Otsu K,Snider P,Conway SJ,Nagai R
J Clin Invest.120(1):254-65. 2010

Endogenous a-calcitonin gene-related peptide mitigates liver fibrosis in chronic hepatitis induced by repeated administration of concanavalin A
Kamiyoshi A, Sakurai T, ShindoY. Iinuma N, Kawate H, YoshizawaT, Koyama T, MutoS, Shindo T
Liver International 29(5): 642-649. 2009.

Crystal structure of the human receptor activity-modifying protein 1 extracellular domain.
Kusano S, Kukimoto-Niino M, Akasaka R, Toyama M, Terada T, Shirouzu M, Shindo T, Yokoyama S.
Protein Sci. 17(11):1907-14. 2008

Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9
Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H
J Biol Chem. 283(36): 24682-9. 2008

The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity
Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T
J Clin Invest. 118(1): 29-39. 2008

Production of characterization of transgenic mice systemically expressing endo b-galactosidase C.
Watanabe S, Misawa M, Matsuzaki T, Sakurai T, Muramatsu T, Yokomine T, Sato M.
Glycobiology. 18(1):9-19.. 2008

Rapid zygosity determination in mice by SYBR Green real-time genomic PCR of a crude DNA solutiion
Sakurai T, Kamiyoshi A, Watanabe S, Sato M, Shindo T
Transgenic Res. 17(1): 149-55. 2008

Adrenomedullin insufficiency increases allergen-induced airway hyperresponsiveness in mice
Yamamoto H, Nagase T, Shindo T, Teramoto S, Aoki-Nagase T, Yamaguchi Y, Hanaoka Y, Kurihara H, Ouchi Y
J Appl Physiol. 102(6): 2361-8. 2007

Disruption of mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in oocytes and somatic cells.
Nakanishi T, Kumagai S, Kimura M, Watanabe H, Sakurai T, Kimura M, Kashiwabara S, Baba T.
Biochem Biophys Res Commun. 364::14-19.,2007

Endogenous αCGRP protects against concanavalin A-induced hepatitis in mice
Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Fukuchi J, Kawate H, Muto S, Tagawa Y, Shindo T
Biochem Biophys Res Commun. 343(1): 152-8. 2006

The synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6
Takeda N, Manabe I, Shindo T, Iwata H, Iimuro S, Kagechika H, Shudo K, Nagai R
Arterioscler Thromb Vasc Biol. 26(5): 1177-83. 2006

Folliculogenesis following syngeneic transplantation of young murine ovaries into the testes
Sato M, Sakurai T, Kiryu K, Takeda M, Yasuoka Y
Reprod Med Biol. 5: 71-77. 2006

Preparation of enzymatically active human Myc-tagged NCre recombinase exhibiting immunoreactivity with anti-Myc antibody
Watanabe S, Homma D, Furusawa T, Sakurai T, Sato M
Mol Reprod Dev. 73:1345- 1352. 2006

Strain difference in tolerance to low-temperature treatment of fertilized mouse oocyte
Sakurai T, Watanabe S, Kimura M, Sato M
Reprod Med Biol. 5:43-50. 2006

Testatin transgenic and knockout mice exhibit normal sex-differentiation
Hasegawa K, Chuma S, Tada T, Sakurai T, Tamura M, Suemori H, Nakatsuji N
Biochem Biophys Res Commun. 341: 369-375. 2006

Significance of the transcription factor KLF5 in cardiovascular remodeling
Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I
J Thromb Haemost. 3(8): 1569-76. 2005

Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation
Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G, Maemura K, Yamauchi T, Kubota N, Suzuki R, Kitamura T, Akira S, Kadowaki T, Nagai R.
Cell Metabolism 1: 27-39. 2005

Synthetic Retinoid Am80 Supresses Smooth Muscle Phenotypic Modulation and In-Stent Neointima Formation By Inhibiting KLF5
Fujiu K, Manabe I, Ishihara A, Oishi Y, Iwata H, Nishimura G, Shindo T, Maemura K, Kagechika H, Shudo K, Nagai R
Cic Res. 97(11): 1132-41. 2005

Angiogenic effects of adrenomedullin in ischemia and tumor growth.
Iimuro S, Shindo T, Moriyama N, Amaki T, Niu P, Takeda N, Iwata H, Zhang Y, Ebihara A, Nagai R:
Circ Res 95:(4):415-23. 2004

Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis and renal damage.
Niu P, Shindo T, Iwata H, Iimuro S, Takeda N, Zhang Y, Ebihara A, Suematsu Y, Kangawa K, Hirata Y, Nagai R:
Circulation 109::1789-1794. 2004

Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa.
Fukushima Y, Matsui T, Saitoh T, Ichinose M, Tateishi K, Shindo T, Fujishiro M, Sakoda H, Shojima N, Kushiyama A, Fukuda S, Anai M, Ono H, Oka M, Shimizu Y, Kurihara H, Nagai R, Ishikawa T, Asano T, Omata M.
Eur J Pharmacol. 502(3):243-52, 2004

KLF5/BTEB2, a Kruppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy.
Nagai R, Shindo T, Manabe I, Suzuki T, Kurabayashi M.
Adv Exp Med Biol. 538::57-65, 2003

Accelerated cardiac hypertrophy and renal damage induced by angiotensin II in adrenomedullin knockout mice.
Niu P, Shindo T, Iwata H, Ebihara A, Suematsu Y, Zhang Y, Takeda N, Iimuro S, Hirata Y, Nagai R:
Hypertens Res :26: 731-36, 2003

Structural and functional characterization of gastric mucosa and central nervous system in histamine H(2) receptor-null mice.
Fukushima Y, Shindo T, Anai M, Saitoh T, Wang Y, Fujishiro M, Ohashi Y, Ogihara T, Inukai K, Ono H, Sakoda H, Kurihara Y, Honda M, Shojima N, Fukushima H,, Haraikawa-Onishi Y, Katagiri H, Shimizu Y, Ichinose M, Ishikawa T, Omata M, Nagai R, Kurihara H, Asano T
Eur J Pharmacol 468(1)::47-58, 2003

Targeted disruption of adrenomedullin and alphaCGRP genes reveals their distinct biological roles.
Kurihara H, Shindo T, Oh-Hashi Y, Kurihar Y, Kuwaki T
Hypertens Res 26 Suppl:S105-8, 2003

Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice.
Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Suzuki E, Sata M, Satonaka H, Takeda R, Nagata D, Kakoki M, Hayakawa H, Kangawa K, Matsuo H, Kitamura T, Nagai R
Hypertens Res 26 Suppl: S79-84, 2003

Gene expression in fibroblasts and fibrosis.Involvement in cardiac hypertrophy
Manabe I, Shindo T, Nagai R:
Circ Res 27::1103-1113, 2002

A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy
Yokoyama H, Wada T, Kobayashi K, Kuno K, Kurihara H, Shindo T, Matsushima K:
Nephrol Dial Transplant 17 Suppl 9::39-41, 2002

Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice.
Aoki-Nagase T, Nagase T, Oh-Hashi Y, Shindo T, Kurihara Y, Yamaguchi Y, Yamamoto H, Tomita T, Ohga E, Nagai R, Kurihara H, Ouchi Y:
Am J Physiol Lung Cell Mol Physiol 283(5)::L963-70, 2002

Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.
Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Suzuki T, Morita H, Maemura K, Sata M, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R:
Nature Medicine 8(8):856-63, 2002

Resistance to neointimal hyperplasia and fatty streak formation in adrenomedullin overexpression mice.
Imai Y, Shindo T, Maemura K, Sata M, Saito Y, Kurihara Y, Akishita M, Osuga J, Ishibashi S, Tobe K, Morita H, Oh-hashi Y, Suzuki T, Maekawa H, Kangawa K, Minamino N, Yazaki Y, Nagai R, Kurihara H:
Arterioscler Thromb Vasc Biol 22(8):1310-5, 2002

Regulation of angiogenesis by the aging suppressor gene klotho.
Fukino K, Suzuki T, Saito Y, Shindo T, Amaki T, Kurabayashi M, Nagai R:
Biochem Biophys Res Commun 293:332-7, 2002

Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury. Studies on transgenic/knockout mice of adrenomedullin gene
Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Kakoki M, Nagata D, Hayakawa H, Satonaka H, Sata M, Tojo A, Suzuki E, Kangawa K, Matsuo H, Kitamura T, Nagai R:
Circ Res 90:657-63, 2002

Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1.
Shindo T, Kurihara H, Maemura K, Kurihara Y, Ueda O, Suzuki H, Kuwaki T, Ju K-H, Wang Y, Ebihara A, Nishimatsu H, Moriyama N, Fukuda M, Akimoto Y, Hirano H, Morita H, Kumada M, Yazaki Y, Nagai R, Kimura K:
J. Mol. Med 80(2):105-16, 2002

Evidence for the physiological and pathological roles of adrenomedullin from genetic engineering in mice.
Imai Y, Shindo T, Maemura K, Kurihara Y, Ryozo N, Kurihara H:
Ann N Y Acad Sci 947:26-33, 2001

Elevated sympathetic nervous activity in mice deficient in αCGRP.
Oh-hashi Y,* Shindo T* (*double 1^stauthor), Kurihara Y, Imai T, Wang Y, Morita H, Imai Y, Kayaba Y, Nishimatsu H, Suematsu Y, Hirata Y, Yazaki Y, Nagai R, Kuwaki T, Kurihara H:
Circ Res 89:983-90, 2001

Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.
Shindo T, Kurihara Y, Nishimatsu H, Moriyama N, Kakoki M, Wang Y, Imai Y, Ebihara A, Kuwaki T, Ju K-H, Minamino N, Kangawa K, Ishikawa T, Fukuda M, Akimoto Y, Kawakami H, Imai T, Morita H, Yazaki Y, Nagai R, Hirata H, Kurihara H:
Circulation 104:1964-71, 2001

Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice.
Imai T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H, Suematsu M, Katayama S:
Circ Res 89(1):55-62, 2001

Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury.
Morita H, Kurihara H, Yoshida S, Saito Y, Shindo T, Oh-Hashi Y, Kurihara Y, Yazaki Y, Nagai R:
Circulation 103(1):133-9, 2001

ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function.
Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Imai T, WangY, Oh-hashi Y, Morita H, Ishikawa T, Yazaki Y, Matsushima K:
J Clin Invest 105(10):1345-52, 2000

Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature.
Shindo T, Kurihara H, Maemura K, Kurihara Y, Kuwaki T, Izumida T, Minamino N, Ju K, Morita H, Oh-hashi Y, Kumada M, Kangawa K, Nagai R, Yazaki Y
Circulation 101(19):2309-16, 2000

Evidence for association between paraoxonase gene polymorphisms and atherosclerotic diseases.
Imai Y, Morita H, Kurihara H, Sugiyama T, Kato N, Ebihara A, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Yazaki Y:
Atherosclerosis 149(2):435-42, 2000

Responses of blood pressure and catecholamine metabolism to high salt loading in endothelin-1 knockout mice.
Morita H, Kurihara H, Kurihara Y, Kuwaki T, Shindo T, Oh-hashi Y, Kumada M, Yazaki Y
Hypertens Res 22(1):11-6, 1999

Polymorphism of the methionine synthase gene : association with homocysteine metabolism and late-onset vascular diseases in the Japanese population.
Morita H, Kurihara H, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Yazaki Y:
Arterioscler Thromb Vasc Biol 19(2):298-302, 1999

Upregulation of endothelin-1 and adrenomedullin gene expression in the mouse endotoxin shock model.
Shindo T, Kurihara H, Kurihara Y, Morita H, Yazaki Y:
J Cardiovasc Pharmacol 31:S541-4, 1998

Cardiac sarcoidosis.
Shindo T, Kurihara H, Ohishi N, Morita H, Maemua K, Kurihara Y, Tsuneyoshi H, Chi H, Yamaoki K, Yazaki Y:
Circulation 97(13):1306-7, 1998

Systemic and renal response to salt loading in endothelin-1 knockout mice.
Morita H, Kurihara H, Kurihara Y, Shindo T, Kuwaki T, Kumada M, Yazaki Y:
J Cardiovasc Pharmacol 31:S557-60, 1998

Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese
Morita H, Kurihara H, Tsubaki S, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Kitamura K, Yazaki Y:
Arterioscler Thromb Vasc Biol 18(9):1465-9, 1998

Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease.
Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yazaki Y:
Circulation 95(8):2032-6, 1997

Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines.
Shindo T, Ikeda U, Ohkawa F, Kawahara Y, Yokoyama M, Shimada K:
Cardiovasc Res 29(6):813-9, 1995

Aneurysmal dilatation of the pulmonary trunk with mild pulmonic stenosis.
Shindo T, Kuroda T, Watanabe S, Hojo Y, Sekiguchi H, Shimada K:
Intern Med 34(3):199-202, 1995

Nitric oxide synthesis in rat cardiac myocytes and fibroblasts.
Shindo T, Ikeda U, Ohkawa F, Takahashi M, Funayama H, Nishinaga M, Kawahara Y, Yokoyama M, Kasahara T, Shimada K
Life Sci 55(14):1101-8, 1994

Tea catechin, epigallocatechin-3-gallate, inhibits rubratoxin B-induced apoptosis of hepatocytes through MAPK p38 pathway
Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K
Micotoxins 55(1): 17-22, 2005

Interaction of rubratoxin B with serum albumin.
Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K
Micotoxins 55(1): 23-26, 2005

Tumor necrosis factor-alpha is required for gastritis induced by Helicobacter felis infection in mice.
Hasegawa S, Nishikawa S, Miura T, Saito Y, Madarame H, Sekikawa K, Tagawa Y, Iwakura Y, Nakane A
Microb. Pathog. 37(3): 119-124, 2004

Comparative study on adhesive performance of functional monomers.
Yoshida, Y., Nagakane K, Fukuda R, Nakayama Y, Okazaki M, Shintani H, Inoue S, Tagawa Y, Suzuki K, Munck J.De, Meerbeek B.Van
J. Dental Research, 83(6): 454-458, 2004

Liver protection by bis(maltolato)zinc(II) complex.
Kawase, M., Kagaya N, Akamatsu S, Kamiyoshi A, Muto S, Tagawa Y, Yagi K
Exp. Anim 53(1): 1-9, 2004

Novel function of rare catechin, epigallocatechin-3-(3’’-O-methyl)gallate, against cold injury in primary rat hepatocytes.
Kagaya, N., Hara Y, Saijo R, Kamiyoshi A, Tagawa Y, Kawase M, Yagi K
J. Biosci. Bioeng. 96(6): 559-563, 2003

Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on FcgR and IFN-g.
Sehra, S, Pynaert G, Tournoy K, Haegenman A, Matthys, P, Tagawa, Y, Pauwels R, Grooten J
J. Immunol. 171(4): 2080-2089, 2003

Survival and function of mouse embryonic stem cell-derived cardiomyocytes in ectopic transplants.
Johkura K, Cu L, Suzuki A, Teng R, Kamiyoshi A, Okamura S, Kubota S, Zhao X, Asanuma K, Okouchi Y, Ogiwara N, Tagawa Y, Sasaki K
Cardiovasc Res. 58(2): 435-443, 2003

Differences between BALB/c and C57BL/6 mice in mouse hepatitis virus replication in primary hepatocyte culture.
Kyuwa S, Kawamura S, Tagawa Y, Iwakura Y, Urano T, Yoshikawa Y
Exp. Anim.. 52(1): 81-84, 2003

IL-1-induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-g-inducible protein 10 in the elicitation phase of the contact hypersensitivity response.
Nakae S, Komiyama Y, Narumi S, Sudo K, Horai R, Tagawa Y, Sekikawa K, Matsushima K, Asano M, Iwakura Y
Int. Immunol. 15(2) : 251-260, 2003

Suppression of cytotoxin-induced cell death in isolated hepatocytes by tea catechins.
Kagaya N, Tagawa Y, Nagashima H, Saijo R, Kawase M, Yagi K
Eur. J. Pharmacol. 450(3): 231-236, 2002

Inhibition of B16 melanoma experimental metastasis by interferon-gamma through direct inhibition of cell proliferation and activation of anti-tumor host mechanisms.
Kakuta S, Tagawa Y, Shibata S, Nanno M, Iwakura Y:
Immunology. 105(1): 92-100, 2002

Comparison of host resistance to primary and secondary Listeria monocytogenes infections in mice by intranasal and intravenous routes.
Mizuki M, Nakane A, Sekikawa K, Tagawa Y, Iwakura Y
Infect. Immun. 70(9): 4805-4811, 2002

Roles of gamma interferon and tumor necrosis factor-alpha in shiga toxin lethality.
Sasaki S, Omoe K, Tagawa Y, Iwakura Y, Sekikawa K, Shinagawa K, Nakane A
Microbial Pathogenesis. 33(1): 43-47, 2002.

Acute hepatic failure in IFN-g-deficient BALB/c mice after murine coronavirus infection.
Kyuwa S, Shibata S, Tagawa Y, Iwakura Y, Machii K, Urano T:
Virus Res. 83(1-2): 169-177, 2002

Enhancing effect of zinc on hepatoprotectivity of epigallocatechin gallate in isolated rat hepatocytes.
Kagaya N, Kawase M, Maeda H, Tagawa Y, Nagashima H, Ohmori H, Yagi K:
Biol.Pharm.Bull. 25(9): 1156-1160, 2002

Effect of 6-hydroxydopamine on host resistance against Listeria monocytogenes infection
Miura T, Kudo T, Matsuki A, Sekikawa K, Tagawa Y, Iwakura Y, Nakane A:
Infect. Immun. 69(12): 7234-7241, 2001

Organ infectivity of Toxoplasma gondii in interferon-gamma knockout mice.
Norose K, Mun.H.S, Aosai F, Chen M, Hata H, Tagawa Y, Iwakura Y, Yano A:
J. Parasitol. 87(2): 447-452, 2001

A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage plasmodium berghei XAT Infection.
Yoneto T, Waki S, Takai T, Tagawa Y, Iwakura Y, Mizuguchi J, Nariuchi H, Yoshimoto T
J. Immunol. 166(10): 6236-6241, 2001

The severity of hepatic lesion after intraperitoneal JHMV infection in IFN-gamma deficient mice is parallel to viral replication in hepatocytes in vitro.
Kyuwa S, Kawamura S, Shibata S, Machii K, Tagawa Y, Iwakura O, Urano T
Adv Exp Med Biol. 494: 95-99, 2001

Bimodal role of endogenous interleukin-6 in concanavalin A-induced hepatitis in mice.
Tagawa Y, Matthys P, Heremans H, Dillen C, Zaman Z, Iwakura Y
J. Leukoc. Biol. 67(1): 90-96, 2000

Lipopolysaccharide-induced HIV-1 expression in transgenic mice is mediated by tumor necrosis factor-α and interleukin-1, but not by interferon-g nor interleukin-6.
Tanaka J, Ozaki H,Yasuda J, Horai R, Tagawa Y, Asano M, Saijo S, Imai M, Sekikawa K, Kopf M, Iwakura Y
AIDS 14(10): 1299-1307, 2000

Interleukin-4 and interleukin-10 are involved in host resistance to Staphylococcus aureus infection through regulation of gamma interferon.
Sasaki S., Nishikawa S, Miura T, Mizuki M, Yamada K, Madarame H, Tagawa Y, Iwakura Y, Nakane A. :
Infect. Immun. 68(5): 2424-2430, 2000

Roles of endogenous cytokines in liver apoptosis of mice in lethal Listeria monocytogenes infection.
Miura T, Nishikawa S, Sasaki S, Yamada K, Hasegawa S, Mizuki D, Mizuki M, Hatayama I, Sekikawa K, Tagawa Y, :Iwakura Y, Nakane A
FEMS Immunol. Med. Microbiol. 28(4): 335-341, 2000

Toxoplasma gondi Hsp 70 as a danger signal in Tosoplasma gondii-infected mice.
Mun H.S, Aosai F, Norose K, Chen M, Hata H, Tagawa Y, Iwakura Y, Byun D.S, Yano A
Cell stress Chaperones. 5(4): 328-335, 2000

Interferon-g priming is not critical for IL-12 production of murine spleen cells.
Hino A, Igarashi O, Tagawa Y, Iwakura Y, Nariuchi H
Cytokine. 12(1): 12-20, 2000

Hematological characteristics of rats spontaneously developing eosinophilia.
Matsumoto K, Matsushita N, Tomozawa H, Tagawa.Y
Exp. Anim. 49(3): 211-215, 2000

　　　　　　　　　　　　　　　　　　　　　　　

　　　　　